🎥 Spike Protein From CORONAVIRUS – SARS-CoV-2 Inside Nucleus ENHANCING DNA DAMAGE?
There was an article published on 10/13/21 that demonstrated spike protein inside the nucleus of transfected HEK293T cells (human embryonic kidney cells) significantly impaired DNA damage repair and inhibited V (D) J recombination (a process that allows immature T-cells and B-cells to produce diverse kinds of antigen receptors/antibodies). In this video I will explain everything you need to know about the previously stated research. For instance, first, I will explain the important points from this publication. Second, I will go over how normal DNA damage repair works. Third, I will go over how altered DNA damage repair works while spike proteins and NSPs (non-structural proteins) are inside the nucleus, all while explaining the POSSIBLE implications of what said data is suggesting for human health. It is important to note that the authors of this publication shine light on the issue of what exposure to full length spike protein could do to the human body. See key points below for a breakdown of important details from this publication. WATCH VIDEO BY CLICKING ABOVE 👆🏻
(CHEAT SHEET FOR THIS STUDY CAN BE FOUND IN MY PREVIOUS POST TITLED: 🦠 SPIKE PROTEIN ENTERS NUCLEUS CHEAT SHEET)
KEY POINTS:
1.) Full length spike protein concentrates in nucleus
2.) Full length spike protein seems to drastically limit BRCA1 and 53BP1 recruitment to site of DNA damage
3.) BRCA1 & 53BP1 are key players in DSB repair (double strand DNA breaks)
4.) NSP’s (non-structural proteins) were also found in nucleus
5.) Because of BRCA1 recruitment reduction, HR repair pathway suppression occurred
6.) Because of BRCA1 recruitment reduction, NHEJ pathway suppression occurred
7.) In this data, HEK293 cells (human embryonic kidney cells) were transfected with full length spike protein
8.) V (D) J recombination was reduced while full length spike protein was in nucleus
9.) Compared to empty vector, full length spike protein transfected cells exhibited more DNA damage
10.) Author states DNA damage repair being altered could contribute to amplification of viral pathology
RESEARCH:
https://www.mdpi.com/1999-4915/13/10/2056/htm
https://www.ncbi.nlm.nih.gov/pmc/articles/mid/NIHMS263012/
https://www.nature.com/articles/nrm3719
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31291/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990114/
https://www.frontiersin.org/articles/10.3389/fmicb.2014.00296/full
LETS CONNECT: